Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis

ChemPhysChem - A European Journal of Chemical Physics and Physical Chemistry vol. 5  p. 1045-1049  DOI: 10.1002/cphc.200400091
PMID/PMCID: 15298394 Published: 2004-07-19 

Carlos Silva-Lopez, Olalla Nieto-Faza, Brent A. Gregersen, Xabier Lopez, Angel Rodriguez de Lera, Darrin M. York [ ]

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Model intermediates: Catalytic mechanisms of RNA transphosphorylation are investigated by monitoring changes in the reaction rate that occur upon substitution of key phosphate oxygen atoms with sulfur atoms. The mechanisms and barriers to pseudorotation for a series of oxyphosphorane and thiophosphorane molecules are presented (see picture). Theoretical models provide detailed insight into biological phosphorous reactivity in RNA systems.