Log In Successful

Profile

Colin S. Gaines

flag

Position: Graduate Researcher
Education:
Pennsylvania State University - B.S. Chemistry (2014)
Email: colin.gaines[at]rutgers.edu
Office: CIPR-308


About Me:

My research focuses on investigating the structure, dynamics, and reaction mechanism of the twister ribozyme through the use of a variety of computation tools including MD, QM/MM, and Constant pH MD simulations.





Publications:

The L-platform/L-scaffold framework: a blueprint for RNA-cleaving nucleic acid enzyme design

(2020) 26, 111-126
DOI: 10.1261/rna.071894.119
Read More   View Full Article   Download PDF   
An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes

(2019) 14, 1068-1076
DOI: 10.1021/acschembio.9b00202
Read More   View Full Article   Download PDF   
Cleaning Up Mechanistic Debris Generated by Twister Ribozymes Using Computational RNA Enzymology

(2019) 9, 5803-5815
DOI: 10.1021/acscatal.9b01155
Read More   View Full Article   Download PDF   
Model for the Functional Active State of the TS Ribozyme from Molecular Simulation

(2017) 56, 13392-13395
DOI: 10.1002/anie.201705608
Read More   View Full Article   Download PDF   
Ribozyme catalysis with a twist: the active state of the twister ribozyme in solution predicted from molecular simulation

(2016) 138, 3058-3065
DOI: 10.1021/jacs.5b12061
Read More   View Full Article   Download PDF