General Reaction Table information
Name Description
P(O)(O)(OCH3)(OCH3)_nucl Effect of nucleophile on in-line dianionic mechanism of nucleophilic substitution of dimethyl phosphate

Dianionic reactions involving di-methyl phosphate
GAS PCM COSMO
Nucleophile ΔG ΔG ΔGaq ΔG aq ΔGaq ΔG aq
di-anionic reactions
HO- 98.16 (-110.13) -11.97 47.58 (-42.64) 4.94 49.46 (-41.41) 8.05
CH3O- 105.82 (-105.82) -0.00 43.56 (-43.56) -0.00 42.31 (-42.31) -0.00
CH3COO- 116.51 (-83.97) 32.54 68.84 (-40.47) 28.37 66.96 (-41.15) 25.81
In-line dianionic nucleophile substitution of dimethyl phosphate:
Nu(-)...P(O)(O)(-O-CH2CH2-O-)(-) ---> P(O)(O)(Nu)(-O-CH2CH2-O)(2-)