Rutgers Main | CIRC | Quantitative Biology   
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Michael E. Harris

A Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme Activation

ACS Catal., (2016) 6, 1853-1869
DOI: 10.1021/acscatal.5b02158 Download PDF

Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn2+

Chem Commun (Camb)., (2016) 52, 4462-4465
DOI: 10.1039/C5CC10212J Download PDF

Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism

Biochim Biophys Acta, (2015) 1854, 1801-1808
DOI: 10.1016/j.bbapap.2015.04.022 Download PDF

Enzyme transition states from theory and experiment

Biochim. Biophys. Acta, (2015) 1854, 1727–1728
DOI: 10.1016/j.bbapap.2015.08.006 Download PDF

Determination of hepatitis delta virus ribozyme N(–1) nucleobase and functional group specificity using internal competition kinetics

Anal. Biochem., (2015) 483, 12-20
DOI: 10.1016/j.ab.2015.04.024 Download PDF

Heavy Atom Labeled Nucleotides for Measurement of Kinetic Isotope Effects

Biochim. Biophys. Acta, (2015) 1854, 1737-1745
DOI: 10.1016/j.bbapap.2015.03.007 Download PDF

Interpretation of pH–Activity Profiles for Acid–Base Catalysis from Molecular Simulations

Biochemistry, (2015) 54, 1307-1313
DOI: 10.1021/bi5012833 Download PDF

Assessment of Metal-Assisted Nucleophile Activation in the Hepatitis Delta Virus Ribozyme from Molecular Simulation and 3D-RISM

RNA, (2015) 21, 1-12
DOI: 10.1261/rna.051466.115 Download PDF

Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects

Biochim. Biophys. Acta, (2015) 1854, 1795-1800
DOI: 10.1016/j.bbapap.2015.02.022. Download PDF

Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation

Curr. Opin. Chem. Biol., (2014) 21C, 96-102
DOI: 10.1016/j.cbpa.2014.06.010. Download PDF

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