I have deep interests in the development of new theoretical methods to study complex biological problems. My first research experience was as an undergraduate student doing a summer internship at the Cornell Theory Center, and later at the Pittsburg Supercomputing Center. I did my graduate work at the University of North Carolina at Chapel Hill, my thesis work involving the study of nucleic acids using molecular dynamics simulations, and the development of new methods for calculating electrostatic interactions of large systems, including the particle-mesh Ewald method. After graduating, I was an NSF postdoctoral fellow with Prof. Weitao Yang at Duke University, here I worked on linear-scaling electronic structure methods. Next, I took an NIH postdoctoral fellowship to work with Prof. Martin Karplus at Harvard to begin work on multiscale models to study complex biological problems (Prof. Karplus was a recipient of the 2013 Nobel Prize in Chemistry for his far-reaching work on multi-scale modeling). My work with Prof. Karplus continued with an EMBO fellowship at the Universite Louis Pasteur in Strasbourg, France, until I moved to my first faculty position at the University of Minnesota Twin Cities in 2000. In 2010, I was recruited to Rutgers as a tenured full Professor, along with with my research group, where we embarked on some extremely exciting new research directions in the development and application of multi-scale models. A continuing application interest throughout my career has been in study of nucleic acids, and in particular RNA, which has any fascinating properties, including the ability to catalyze important biochemical reactions and perform complex regulatory functions in cells.