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New Publications

Active participation of Mg2+ ion in the reaction coordinate of RNA self-cleavage catalyzed by the hammerhead ribozymes

DOI: 10.1021/ct100467t Download PDF

Accurate proton affinity and gas-phase basicity values of molecules important in biocatalysis

J. Phys Chem. B, (2010) 114, 13911-13921
DOI: 10.1021/jp107450n Download PDF

Computational mutagenesis studies of hammerhead ribozyme catalysis

J. Am. Chem. Soc., (2010) 132, 13505-13518
DOI: 10.1021/ja105956u Download PDF

Insights into the Role of Conformational Transitions and Metal Ion Binding in RNA Catalysis from Molecular Simulations

DOI: 10.1016/S1574-1400(10)06001-9 Download PDF

Molecular dynamics simulation of bovine pancreatic ribonuclease A - CpA and transition state-like complexes

J. Phys. Chem. B, (2010) 21, 7371-7382
DOI: 10.1021/jp909004y Download PDF

Identification of dynamical hinge points of the L1 ligase molecular switch

RNA, (2010) 16, 769-780
DOI: 10.1261/rna.1897810 Download PDF

Exocyclic deoxyadenosine adducts of 1,2,3,4-Diepoxybutane: Synthesis, structural elucidation, and mechanistic studie

Chem. Res. Toxicol., (2010) 23, 118-133
DOI: 10.1021/tx900312e Download PDF

Threshold occupancy and specific cation binding modes in the hammerhead ribozyme active site are required for active conformation

J. Mol. Biol., (2009) 388, 195-206
DOI: 10.1016/j.jmb.2009.02.054 Download PDF

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